64097-58-1

Usage

Potential applications

Antidepressant and antipsychotic medication

Chemical class

Dibenzoazepine derivatives

Mechanism of action

Potent serotonin and norepinephrine reuptake inhibitor

Affinity

Strong affinity for serotonin and norepinephrine transporters

Therapeutic effects

Modulates levels of serotonin and norepinephrine in the brain

Studied for efficacy in treating

Mood disorders (e.g. depression, bipolar disorder), psychotic disorders (e.g. schizophrenia)

Status of research

Ongoing

Promise

Development of novel treatments for psychiatric conditions

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 494-19-9 9,10-dihydrodibenzazepine 

Relevant academic research and scientific papers

Aminomethylation de l'homoacridane, de l'iminodibenzyle et de l'iminostilbene

The aminomethylation of 6,11-dihydro-5H-dibenzoazepine (HA), 10,11-dihydro-5H-dibenzoazepine (IDB) and dibenzoazepine (ISB) was studied in order to evaluate modifications of antidepressive activities of these tricyclic structures.By reaction with formalin and a secondary amine in ethanol medium acidified by means of acetic acid, homoacridane (HA) leads to a monosubstitution product on carbone 2 (yield 50percent).Iminodibenzyl (IDB) and iminostilbene (ISB) also give monoaminomethylation products in analogous position (yields are respectively 74 and 59percent).In each case, the optimum amount of acetic acid has been determined.If acetic acid is used as the solvent, diaminomethylation is observed in positions 2 and 8 (yiels are 74percent for IDB and 59percent for ISB).Structures of the isolated products have been studied by IR and 1H nmr.The postulated mechanism of aromatic electrophilic substitution is discussed with respect to various factors: differences in basicities of heterocyclic amines; electronic structures and nitrogen activation of aromatic tricyclic systems; influence of amount of acetic acid on salification equilibria.