641-80-5 Usage
Uses
Used in Pharmaceutical Industry:
17-Hydroxypregnenedione is used as a pharmaceutical intermediate for the synthesis of various steroidal drugs, including corticosteroids and sex hormones. It serves as a key building block in the production of these medications, which have wide-ranging applications in treating various medical conditions.
Used in Hormone Replacement Therapy:
In hormone replacement therapy, 17-hydroxypregnenedione is used as a precursor to produce natural progesterone. This hormone plays a vital role in maintaining a healthy menstrual cycle, supporting pregnancy, and addressing symptoms associated with menopause.
Used in Treatment of Adrenal Disorders:
17-Hydroxypregnenedione is used as a diagnostic marker for adrenal disorders, such as congenital adrenal hyperplasia (CAH). Measuring the levels of 17-hydroxypregnenedione in blood samples can help healthcare professionals identify and monitor the progression of these conditions.
Used in Research and Development:
In the field of research and development, 17-hydroxypregnenedione is used as a valuable tool for studying the biosynthesis of steroid hormones and their role in various physiological processes. This knowledge can contribute to the development of novel therapeutic agents and a better understanding of hormonal regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 641-80-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 641-80:
(5*6)+(4*4)+(3*1)+(2*8)+(1*0)=65
65 % 10 = 5
So 641-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,16-18,24H,5-12H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
641-80-5Relevant academic research and scientific papers
Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone
Tian, Yuan,Hong, Yang,Bonacorsi, Samuel J.,Balog, Aaron,Gong, Sharon
, p. 1 - 11 (2014/02/14)
For the first time, [3α-3H] 17α-hydroxy pregnenolone (1) was synthesized through a multiple step sequence. The presence of [3β-3H] isomer in RP-HPLC purified product was identified by tritium NMR. The [3β-3H] isomer was then separated from [3α-3H] 17α-hydroxy pregnenolone with chiralPAK AD-H column. [3α-3H] pregnenolone (2) was synthesized from commercial available 5-pregnen-3,20-dione in one step with an improved procedure. [3α-3H] 17α-hydroxy pregnenolone (1) was synthesized through a multiple step sequence. The presence of [3β- 3H] isomer was identified then separated with chiralPAK AD-H column. [3α-3H] pregnenolone (2) was synthesized from commercial available 5-pregnen-3,20-dione in one step. Copyright
