64102-11-0

Upstream product

• 622-95-7 4-chlorobenzyl bromide 
• 97-62-1 Ethyl isobutyrate 
• 104-88-1 4-chlorobenzaldehyde 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 19366-15-5 4-chloro-β,β-dimethylstyrene 

Downstream Products

• 14248-27-2 3-(4-chlorophenyl)-2,2-dimethylpropan-1-ol 
• 1338684-22-2 1-(3-azido-2,2-dimethylpropyl)-4-chlorobenzene 
• 1268077-56-0 3-(4-chlorophenyl)-2,2-dimethylpropan-1-amine 

Relevant academic research and scientific papers

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.

Studies on the synthesis of chiral 2-(p.chlorophenyl)-3-methylbutanoic acid, a key-precursor of Fenvalerate, by hydrocarbonylation reactions

The preparation of racemic 2-(p.chlorophenyl)-3-methylbutanoic acid (2), a building block for (S,S)-Fenvalerate (an important broad spectrum insecticide), was effected by rhodium catalyzed hydroformylation of 2-methyl-1 -(p.chlorophenyl) propene (4) in the presence of excess of triphenylphosphine to inhibit substrate isomerization followed by mild oxidation of the resulting aldehyde 6; an overall yield of 88% was reached. Olefin 4 exhibits a very low tendency to undergo both hydrocarboethoxylation and hydrocarboxylation in the presence of palladium complexes as catalysts. Enantioselective hydrocarbonylation reactions carried out on olefin 4 afford unsatisfactory chemical and optical yields of the optically active ester 5 or acid 2. Springer-Verlag 1996.