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γ-Carboxyglutamyl-leucine (Glu(γ-COOH)-Leu) is a unique peptide consisting of a γ-carboxyglutamic acid (Gla) residue and a leucine residue. It is a key component of certain proteins, particularly those involved in blood coagulation, such as prothrombin and factors VII, IX, and X. The γ-carboxylation of glutamic acid residues is a post-translational modification that is essential for the biological activity of these proteins, as it allows them to bind calcium ions, which is crucial for their function in the coagulation cascade. This modification is catalyzed by the enzyme γ-glutamyl carboxylase, which requires vitamin K as a cofactor. The presence of γ-carboxyglutamyl-leucine in these proteins is vital for their ability to participate in the clotting process, highlighting its importance in maintaining hemostasis and preventing excessive bleeding.

64153-46-4

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64153-46-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 64153-46-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,1,5 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64153-46:
(7*6)+(6*4)+(5*1)+(4*5)+(3*3)+(2*4)+(1*6)=114
114 % 10 = 4
So 64153-46-4 is a valid CAS Registry Number.

64153-46-4Downstream Products

64153-46-4Relevant academic research and scientific papers

ENZYMATICALLY CATALYZED SYNTHESIS OF DIPEPTIDES OF γ-CARBOXY-L-GLUTAMIC ACID FROM BENZYLOXYCARBONYL-γ-CARBOXY-DL-GLUTAMIC-ACID

Cerovsky, Vaclav,Jost, Karel

, p. 878 - 884 (2007/10/02)

Enantioselective reaction of benzyloxycarbonyl-γ-carboxy-DL-glutamic acid with phenylhydrazines of various amino acids and with leucine, protected with various carboxy-protecting groups, has been studied.

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