641612-76-2Relevant academic research and scientific papers
Sulfonamidolactam inhibitors of coagulation factor Xa
Smallheer, Joanne M.,Wang, Shuaige,Laws, Mia L.,Nakajima, Suanne,Hu, Zilun,Han, Wei,Jacobson, Irina,Luettgen, Joseph M.,Rossi, Karen A.,Rendina, Alan R.,Knabb, Robert M.,Wexler, Ruth R.,Lam, Patrick Y.S.,Quan, Mimi L.
, p. 2428 - 2433 (2008/09/21)
As part of an effort to identify novel backups for previously reported pyrazole-based coagulation Factor Xa inhibitors, the pyrazole 5-carboxamide moiety was replaced by 3-(sulfonylamino)-2-piperidone. This led to the identification of a structurally dive
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
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Page/Page column 45, (2008/06/13)
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
