641613-89-0Relevant academic research and scientific papers
A Facile Synthesis of 2,4-Disubstituted 3-Fluoroquinolines via Intramolecular Cyclization of o-Cyanomethylamino-β,β-difluorostyrenes
Wada, Yukinori,Mori, Takashi,Ichikawa, Junji
, p. 1000 - 1001 (2003)
o-Cyanomethylamino-β,β-difluorostyrenes are treated with base (LiTMP, NaH, or K2CO3) to generate the corresponding carbanions, which in turn readily undergo intramolecular replacement of the vinylic fluorine and subsequent eliminatio
