641615-34-1

Basic information

• Product Name: (E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE
• Synonyms: 3-(DiMethylaMino)-1-(pyriMidin-5-yl)prop-2-en-1-one;(E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE;3-(Dimethylamino)-1-(5-pyrimidinyl)-2-propen-1-one;3-(DiMethylaMino)-1-(5-pyriMidine)-2-propen-1-one;(2E)-3-(dimethylamino)-1-pyrimidin-5-ylprop-2-en-1-one
• CAS NO: 641615-34-1
• Molecular Formula: C₉H₁₁N₃O
• Molecular Weight: 0
• Mol File: 641615-34-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 138-139 °C
• Boiling Point: 291.1°C at 760 mmHg
• Flash Point: 129.8°C
• Appearance: /
• Density: 1.122g/cm³
• Vapor Pressure: 0.00199mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: (E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE(641615-34-1)
• EPA Substance Registry System: (E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE(641615-34-1)

Safety Data

• Hazardous Substances Data: 641615-34-1(Hazardous Substances Data)

Usage

General Description

(E)-3-(dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one is a chemical compound with the molecular formula C11H14N2O. It is a yellow to brown solid that is soluble in ethanol, methanol, and DMSO. (E)-3-(DIMETHYLAMINO)-1-(PYRIMIDIN-5-YL)PROP-2-EN-1-ONE is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has been studied for its potential biological activities, including its use as a potential anti-inflammatory and anti-cancer agent. Additionally, (E)-3-(dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one has also been investigated for potential applications in the field of materials science as a fluorescent dye and in the development of new organic electronic devices.

InChI:InChI=1/C9H11N3O/c1-12(2)4-3-9(13)8-5-10-7-11-6-8/h3-7H,1-2H3/b4-3+

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 10325-70-9 1-(pyrimidin-5-yl)ethan-1-one 

Downstream Products

• 641615-35-2 N-(2-methyl-5-nitrophenyl)-4-(5-pyrimidinyl)-2-pyrimidineamine 

Relevant articles and documents

AMIDE DERIVATIVE AND MEDICINE

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula [1]: (wherein R1 represents -CH2-R11, etc.; R2 represents alkyl, halogen, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.