641616-55-9Relevant academic research and scientific papers
Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM
Baldwin, Ronald M.,Fu, Xing,Kula, Nora S.,Baldessarini, Ross J.,Amici, Louis,Innis, Robert B.,Tamagnan, Gilles D.
, p. 4015 - 4017 (2007/10/03)
The iodobenzamide neuroleptic analogue (S)-N-(1-ethylpyrrolidin-2-ylmethyl) -2-hydroxy-5-iodo-6-methoxybenzamide (5-IBZM) was synthesized stereospecifically and its pharmacological properties were compared with the 3-iodo isomer (IBZM) used for imaging D2 receptors in vivo. The isomer 5-IBZM had 100-fold lower affinity than IBZM and migrated with similar retention time as the byproduct formed during electrophilic iodination of BZM.
