641626-85-9Relevant academic research and scientific papers
Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands
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Page 8, (2010/02/05)
The present invention provides compounds of formula I: 1 in which:one of X and Y is a nitrogen atom substituted by a group R6′ and the other is a carbon atom substituted by an isoxazole group substituted on its carbon atoms by groups R3 and R4;one of R6 and R6′ is hydrogen;either all of W1, W2, W3 and W4 are carbon or one of W1, W2, W3 and W4 is nitrogen and the rest are carbon;and R1 and R2 are, independently, a small group, heteroaromatic ring or a 4-7 membered cyclic amine ring; processes for making them; pharmaceutical composition containing them; their use in therapy, particularly for enhancing cognition in conditions such as Alzheimer''s Disease; and methods of treatment using them.
