64183-49-9Relevant academic research and scientific papers
The first palladium-catalyzed Sonogashira coupling of unactivated secondary alkyl bromides
Altenhoff, Gereon,Würtz, Sebastian,Glorius, Frank
, p. 2925 - 2928 (2007/10/03)
A palladium-carbene catalyzed Sonogashira coupling of unactivated alkyl bromides with alkyl substituted alkynes is reported. For the first time, unactivated secondary alkyl halides were successfully employed in Sonogashira reactions.
ALKYLATION OF STABILIZED ACETYLIDES IN DMSO. PREPARATION OF α,β-ACETYLENIC ALCOHOLS AND ACETALS.
Chong, J. Michael,Wong, Susanna
, p. 5445 - 5448 (2007/10/02)
Stabilized terminal acetylenes 1 2OTHP, Ph, CH(OET)2> may be converted into lithioacetylides and readily alkylated with 1 alkyl halides in DMSO to afford functionalized disubstitued acetylenes.
