642001-42-1

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 78-93-3 butanone 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Iodine-catalyzed ultrasound-assisted construction of pyridines and their glutamine synthetase molecular docking

Iodine-promoted facile protocol is designed for the production of pyridines at room temperature under ultrasound irradiation. Eleven pyridine derivatives in excellent yields (91–97%) are synthesized with 2 hr reaction time. Additional advantage of the pro

SO4 ?2/SnO2–catalyzed cyclocondensation for the synthesis of fully functionalized pyridines

An efficient and promising synthetic approach to assemble skeletons of multifunctionalized pyridine derivatives in presence of recyclable heterogeneous sulfated tin oxide (STO) catalyst has been evolved. The STO catalyst was used as a promoter for the cyc

Poly N,N-dimethylaniline-formaldehyde supported on silica-coated magnetic nanoparticles: a novel and retrievable catalyst for green synthesis of 2-amino-3-cyanopyridines

Preparation and application of novel and reusable magnetic nanoparticles with poly N,N-dimethylaniline-formaldehyde support as a heterogeneous basic catalyst have been described. The reported catalyst was characterized by Fourier transform infrared spectr

Synthesis of a novel and reusable biological urea based acidic nanomagnetic catalyst: Application for the synthesis of 2-amino-3-cyano pyridines via cooperative vinylogous anomeric based oxidation

In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2-amino-3-cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway.

Synthesis of a novel and reusable biological urea based acidic nanomagnetic catalyst: Application for the synthesis of 2-amino-3-cyano pyridines via cooperative vinylogous anomeric based oxidation

In the current study, a novel and reusable biological urea based nano magnetic catalyst namely Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was designed and synthesized. The structure of the titled catalyst was fully characterized using several skills including Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo gravimetric analysis/differential thermal analysis (TG/DTG) and vibrating sample magnetometer (VSM). Then, the catalytic performance of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid was successfully inspected towards the multicomponent synthesis of 2-amino-3-cyano pyridine derivatives through a vinylogous anomeric based oxidation pathway.

Nanomagnetically modified vitamin B3 (Fe3O4@Niacin): An efficient and reusable green biocatalyst for microwave-assisted rapid synthesis of 2-amino-3-cyanopyridines in aqueous medium

Superparamagnetic nanoparticles of modified vitamin B3 (Fe3O4@Niacin) represent a new, efficient and green biocatalyst for the one-pot synthesis of 2-amino-3-cyanopyridine derivatives via four-component condensation reaction between aldehydes, ketones, malononitrile, and ammonium acetate under microwave irradiation in water. This new magnetic organocatalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least six times without significant degradation in the activity. The catalyst was fully characterized by FT-IR, XRD, SEM, VSM, UV–Vis, DLS and EDS. Excellent yield, very short reaction time (7–10?min), operational simplicity, easy work-up procedure, avoidance of hazardous or toxic catalysts and organic solvents are the main advantages of this green methodology which makes it more economic than the other conventional methods.

Zinc-catalyzed multicomponent reactions: Facile synthesis of fully substituted pyridines

A first example of environmentally benign zinc complex catalyzed one-pot four-component reaction between malononitrile, ketone, ammonium acetate and aromatic aldehyde for the facile synthesis of fully substituted pyridines just within 2 min in environment

Silver(i)-N-heterocyclic carbene catalyzed multicomponent reactions: A facile synthesis of multisubstituted pyridines

A four component one-pot reaction between aromatic aldehyde, malononitrile, ammonium acetate and ketone mediated by Ag(i) N-heterocyclic carbene to produce multisubstituted and fused pyridines in a short reaction time (～10 min) in ethanol at room temperat

An efficient method for the multicomponent synthesis of multisubstituted pyridines, a rapid procedure using Au/MgO as the catalyst

Au/MgO proved to be a highly efficient and reusable catalyst for multicomponent coupling reactions at 70 °C. The synthesized multisubstituted pyridines were obtained in high yields and in short reaction times. With facile work-up, the novel catalyst can b