64201-00-9Relevant academic research and scientific papers
Synthesis of Carbamoyl Fluorides via a Selective Fluorinative Beckmann Fragmentation
Lim, Hee Nam,Song, Jin Woo
supporting information, p. 5394 - 5399 (2021/07/26)
A fluorinative Beckmann fragmentation of α-oximinoamides was devised to provide synthetically useful carbamoyl fluorides. High selectivity for fragmentation over a potentially competing Beckmann rearrangement was observed. This protocol has a distinct mechanism and thus a different substrate scope compared with other synthetic methods. α-Oximinoamides derived from the readily available secondary amines, lactams, or isatins were converted into structurally diverse carbamoyl fluorides.
