64205-06-7

Upstream product

• 63422-71-9 (R)-α-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]benzeneacetic acid 

Downstream Products

• 137839-96-4 Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-vinylpenicillanate 
• 137839-98-6 Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-methylthiopenicillanate 
• 69752-33-6 tert-butyl (6R,7R) and (6S,7S)-7-<2R-2(4-ethyl-2,3-dioxo-1-piperidinyl)formamido>-3-trifluoromethyl-3-cephem-4-carboxylate (1:1 mixture) 
• 74529-26-3 (6R,7R) and (6S,7S)-7-<2R-2(4-ethyl-2,3-dioxo-1-piperidinyl)formamido>-3-trifluoromethyl-3-cephem-4-carboxylic acid (1:1 mixture) 
• 137840-00-7 Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-mercaptopenicillanate 
• 137839-99-7 Allyl 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-succinimidopenicillanate 
• 137839-94-2 Sodium 6β-<(2R)-2-(4-Ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-phenylacetamido>-6α-vinylpenicillanate 
• 1407155-93-4 C₃₁H₃₂ClN₉O₆S 
• 86062-39-7 sodium 7β--2-phenylacetamido>-7α-formamido-cephalosporanate 
• 86062-38-6 t-butyl 7β--2-phenylacetamido>-7α-formamidocephalosporanate 
• 86062-37-5 t-butyl 7α-amino-7β--2-phenylacetamido>cephalosporanate 

Relevant academic research and scientific papers

Synthesis and biological activity of 3-(N-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins

The synthesis and antibacterial activity of a series of 3-(1-substituted pyridinium-4-thiomethyl)-7α-formamido cephalosporins is described. All the derivatives showed good potency and stability to bacterial β-lactamases. The antibacterial efficacy seen with the N-alkyl pyridinium substituents was enhanced by the introduction of a catecholic side chain at C-7 and by preparation of N-(substituted amino)pyridinium derivatives.

NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE

The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.

Further Synthetic Studies in Penicillin C(6)-Substitution Including the Versatile 6&α-Succinimidooxy Leaving Group

Treatment of benzyl 6α-dimethylamino-6β-phenoxyacetamidopenicillanate 3 with methyl iodide led, in the absence of added nucleophiles, to the oxygen-bridged dimer 8 via adventitious water present.Added methanol or water led to the 6α-methoxy or -hydroxy pr

Preparation and Properties of 7α-Formamido Cephalosporins

The preparation of novel antibacterially active 7α-formamido cephalosporins from the corresponding 7α-(methylthio) analogues by mercury(II)-mediated displacement with ammonia and subsequent formylation is described.The amine (2), a versatile intermediate,