642085-95-8

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 161110-10-7 3-deoxy-1,2-O-isopropylidene-5-O-(4-methylbenzoyl)-α-D-erythro-pentofuranose 
• 642085-94-7 4-Methyl-benzoic acid (3aR,5R,6S,6aR)-6-(imidazole-1-carbothioyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 561066-30-6 (2S,4R)-2-[(4-methylbenzoyloxy)methyl]tetrahydrofuran-4-ol 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 75096-60-5 1,2-O-isopropylidene-5-O-(4-toluoyl)-D-xylofuranose 
• 24424-99-5 di-tert-butyl dicarbonate 
• 561066-31-7 (2S,4S)-4-azido-2-[(4-methylbenzoyloxy)methyl]tetrahydrofuran 

Downstream Products

• 561066-32-8 (2S,4S)-2-(hydroxymethyl)-4-(tert-butoxycarbonylamino)tetrahydrofuran 
• 561066-46-4 (2R,3R,4R,5R)-N₁-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-N₆-[(2S,4S)-2-(hydroxymethyl)tetrahydrofuran-4-yl]-2,5-dibenzyloxy-3,4-dihydroxyhexanediamide 
• 561066-37-3 ((3S,5S)-5-Formyl-tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Design and synthesis of HIV-1 protease inhibitors. Novel tetrahydrofuran P2/P2′-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex

A series of HIV-1 protease inhibitors having new tetrahydrofuran P2/P2′ groups have been synthesised and tested for protease inhibition and antiviral activity. Six novel 4-aminotetrahydrofuran derivatives were prepared starting from commercially available