64210-60-2

Usage

Uses

Used in Pharmaceutical Industry:
6-Methyl-3-pyridazinecarboxylic acid is used as an intermediate in the production of pharmaceuticals for its ability to participate in various chemical reactions, contributing to the synthesis of new drug molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 6-Methyl-3-pyridazinecarboxylic acid is used as an intermediate in the synthesis of agrochemicals, aiding in the development of new compounds for agricultural applications.
Used in Organic Synthesis:
6-Methyl-3-pyridazinecarboxylic acid is used as a building block in organic synthesis for its versatility in participating in a range of chemical reactions, enabling the creation of diverse organic compounds.

InChI:InChI=1/C6H6N2O2/c1-4-2-3-5(6(9)10)8-7-4/h2-3H,1H3,(H,9,10)

Upstream product

• 49840-90-6 6-methylpyridazine-3-carbonitrile 
• 78490-07-0 2-Benzoyl-6-methyl-2,3-dihydro-pyridazine-3-carbonitrile 

Downstream Products

• 64210-57-7 ethyl 6-methylpyridazine-3-carboxylate 

Relevant academic research and scientific papers

Enzymatic Hydrolysis of Heterocyclic Nitriles

Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp.Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile (8a), indole-3-carbonitrile (9a), and indole-3-ylacetonitrile (10a) the acids were formed.

Selective transformation of nitriles into amides and carboxylic acids by an immobilized nitrilase

Using an immobilized nitrilase from Rhodococcus sp. mild and selective hydrolysis of nitriles can be achieved even in the presence of acid or base sensitive groups under neutral conditions. This method is applicable to a broad range of substrates as exemplified by aliphatic, alicyclic, heterocyclic and carbohydrate type nitriles.

Pyridazines. XXV . Formation of 2-Benzoyl-2,5-dihydro-3-pyridazinecarbonitrile Derivatives in the Reissert Reaction of Pyridazines

Pyridazines 1a,b on treatment with potassium cyanide/benzoyl chloride in a mixed solvent system gave 2-benzoyl-2,5-dihydro-3-pyridazinecarbonitriles 3a,b together with products resulting from attack of one mole of cyanide ion and three moles of benzoyl chloride (5a,b).The structures of these novel compounds are proved.A plausible reaction mechanism is proposed, involving rearrangement of initially formed 2a,b into 3a,b.Furthermore, the synthesis of the pyridazine Reissert compound 2a is reported.

Derivatives of 1,2-dithiole and anti-bilharzia compositions thereof

1,2-Dithiole derivatives of the formula: STR1 wherein Het represents a pyridazin-3-yl radical, or a pyrimidin-2-yl, -4-yl or -5-yl radical, each such radical being optionally substituted by a halogen atom or by an alkyl radical of 1 through 4 carbon atoms, an alkoxy radical of 1 through 4 carbon atoms, the mercapto radical, an alkylthio radical of 1 through 4 carbon atoms or a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical, are new compounds useful in the treatment of bilharziasis and amoebiases.

1,2-Dithiole derivatives

1,2-Dithiole derivatives of the formula: STR1 WHEREIN Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R1 --C(OH)-- in which R1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.