64211-45-6

Basic information

• Product Name: Oxiconazole
• Synonyms: OXICONAZOLC NITRATE;OXICONAZOLE;1-(2,4-Dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-yl-ethanimine;1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone O-(2,4-dichlorobenzyl) oxime
• CAS NO: 64211-45-6
• Molecular Formula: C18H13Cl4N3O
• Molecular Weight: 429.13
• EINECS: 1533716-785-6
• Product Categories: Active Pharmaceutical Ingredients
• Mol File: 64211-45-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 576.8 °C at 760 mmHg
• Flash Point: 302.6 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 1.06E-12mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• PKA: 6.14±0.12(Predicted)
• CAS DataBase Reference: Oxiconazole(CAS DataBase Reference)
• NIST Chemistry Reference: Oxiconazole(64211-45-6)
• EPA Substance Registry System: Oxiconazole(64211-45-6)

Safety Data

• Hazardous Substances Data: 64211-45-6(Hazardous Substances Data)

Usage

Description

Oxiconazole is a substituted imidazole derivative,it is structurally distinct from miconazole, econazole, clotrimazole, and ketoconazole because it is an acetophene-oxime derivative. It has a broad spectrum of antifungal activity including activity against yeasts, dermatophytes, and Aspergillus species.

Uses

Different sources of media describe the Uses of 64211-45-6 differently. You can refer to the following data:
1. Oxiconazole is used as an antifungal agent.
2. Antifungal. Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.

Indications

Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.

Definition

ChEBI: An oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and i which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.

Brand name

Oxistat (Altana).

InChI:InChI=1/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18-

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 64211-06-9 (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime 

Relevant articles and documents

Synthesis process of high-purity oxiconazole nitrate

The invention relates to a synthesis process of high-purity oxiconazole nitrate, and belongs to the technical field of pharmacy, thesynthesis process comprises the following steps: 1, stirring and mixing 2-chloro-1-(2, 4-dichlorophenyl) ethanone, imidazole and absolute methanol, carrying out reflux reaction, adding hydrogen peroxide, ammonia monohydrate and a modified catalyst, continuously reacting, and purifying, and obtaining (Z)-2 '-(1H-imidazole-1-yl)-2, 4-dichloroacetophenone oxime with relatively high purity; 2, (Z)-2 '-(1H-imidazole-1-yl)-2, 4-dichloroacetophenone oxime and 2, 4-dichlorobenzyl chloride are subjected to a substitution reaction, high-purity oxiconazole nitrate is obtained through suction filtration, washing, drying and recrystallization, the traditional synthesis process is analyzed, the synthesis method and the mode of adding a modified catalyst are changed, generation of impurities is reduced, the purity of products in production links is improved, the synthesis steps are reduced, the synthesis route is shortened and the production efficiency is improved.