64214-86-4Relevant academic research and scientific papers
An Organocatalytic Regiospecific Synthesis of 1,5-Disubstituted 4-Thio-1,2,3-triazoles and 1,5-Disubstituted 1,2,3-Triazoles
Ramachary, Dhevalapally B.,Krishna, Patoju M.,Gujral, Jagjeet,Reddy, G. Surendra
supporting information, p. 16775 - 16780 (2015/11/16)
Organocatalytic azide-ketone [3+2] cycloaddition (OrgAKC) of a variety of 1-aryl-2-(arylthio)ethanones and 1-alkyl-2-(alkylthio)ethanones with different aryl or alkyl azides is reported in dimethyl sulfoxide or solvent-free under ambient conditions to furnish 1,5-disubstituted 4-thio-1,2,3-triazoles in a regiospecific manner, which are further converted into useful 1,5-disubstituted 1,2,3-triazoles by treatment with Raney Ni at 25 ?C for 1-3 h. Notable features of the OrgAKC reaction include high rate and selectivity, solvent-free conditions, easily available substrates and catalysts, a wide range of synthetic and medicinal applications, and excellent yields generating a vast library of triazoles.
Triazolines. 14. 1,2,3-Triazolines and Triazoles, a New Class of Anticonvulsants. Drug Design and Structure-Activity Relationships
Kadaba, Pankaja
, p. 196 - 203 (2007/10/02)
Pioneering studies in our laboratory have led to the emergence og the Δ2-1,2,3-triazolines (4,5-dihydro-1H-1,2,3-triazoles) and the closely related 1H-1,2,3-triazoles as a unique family of anticonvulsant agents hitherto unknown.Unlike the tradi
