64218-24-2 Usage
Description
1-(2-Chloroethyl)-1-nitroso-3-(2β,3β,4β,5β-tetrahydroxycyclopentan-1α-yl)urea, also known as TCNU, is a nitrogen mustard compound derived from the classical alkylating agent nitrogen mustard. It possesses antineoplastic and immunosuppressive properties, exerting its cytotoxic effects by alkylating DNA, which interferes with DNA replication and ultimately leads to cell death. TCNU is a promising pharmaceutical candidate for various applications due to its potential in treating cancers and as an immunosuppressive agent.
Uses
Used in Anticancer Applications:
TCNU is used as an antineoplastic agent for the treatment of various cancers, including lymphoma and solid tumors. It modulates several cellular processes by alkylating DNA, exerting inhibitory effects on tumor growth and progression.
Used in Immunosuppression:
TCNU is used as an immunosuppressive agent in the prevention of acute rejection in organ transplantation. Its immunosuppressive properties have shown promise in clinical trials, enhancing the success rate of organ transplants by reducing the risk of rejection.
Used in Pharmaceutical Industry:
TCNU is used as a key compound in the development of new drugs for cancer treatment and immunosuppression. Its unique mechanism of action and potential applications make it a valuable asset in the pharmaceutical industry for the creation of novel therapeutics.
Used in Research and Development:
TCNU is utilized in research and development for understanding the mechanisms of DNA alkylation and its effects on cancer cells and the immune system. This knowledge can contribute to the advancement of cancer therapies and immunosuppressive treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 64218-24-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,2,1 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64218-24:
(7*6)+(6*4)+(5*2)+(4*1)+(3*8)+(2*2)+(1*4)=112
112 % 10 = 2
So 64218-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H14ClN3O6/c9-1-2-12(11-18)8(17)10-3-4(13)6(15)7(16)5(3)14/h3-7,13-16H,1-2H2,(H,10,17)/t3?,4-,5+,6-,7+
64218-24-2Relevant articles and documents
1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antitumor agents
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, (2008/06/13)
Novel water-soluble nitrosourea derivatives of the formula STR1 WHEREIN R represents a 2', 3', 4', 5'-tetrahydroxycyclopentyl group exhibit high effectiveness in various animal tumor systems.
