64224-68-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinecarboxylicacid, 2-(dimethylamino)-, ethyl ester is used as a key intermediate in the development of new drugs, particularly in oncology and neuroscience. Its unique structure allows for the creation of compounds that can target and treat various types of cancer and neurological disorders.
Used in Agricultural Industry:
In agriculture, 5-Pyrimidinecarboxylicacid, 2-(dimethylamino)-, ethyl ester may have applications as a pesticide or herbicide. Its chemical properties can be harnessed to control pests and weeds, contributing to more effective and sustainable agricultural practices.
Overall, 5-Pyrimidinecarboxylicacid, 2-(dimethylamino)-, ethyl ester is a versatile chemical compound with significant potential in both the pharmaceutical and agricultural sectors, offering a wide range of applications for the development of innovative products and solutions.

InChI:InChI=1/C9H13N3O2/c1-4-14-8(13)7-5-10-9(11-6-7)12(2)3/h5-6H,4H2,1-3H3

Upstream product

• 311-77-3 1,1-dimethylguanidine dihydrogensulfate 
• 54127-87-6 ethyl 6-chloro-2-dimethylaminopyrimidine-5-carboxylate 
• 7440-66-6 zinc 

Downstream Products

• 5621-02-3 2-(dimethylamino)pyrimidine 

Relevant academic research and scientific papers

Synthesis and cardiotonic activity of novel pyrimidine derivatives: Crystallographic and quantum chemical studies

The synthesis of ethyl or methyl 4-substituted or unsubstituted 2- (dimethylamino)-5-pyrimidinecarboxylates 10-20, which is mainly carried out by reaction of ethyl or methyl 2-[(dimethylamino)methylene]-3-oxoalkanoates with 1,1-dimethylguanidine, is described. The above esters were hydrolyzed to the relative carboxylic acids 21-30, which were decarboxylated to the corresponding 2,4-disubstituted pyrimidines 31-40. All the new synthesized pyrimidines were evaluated in spontaneously beating and electrically driven atria from reserpine-treated guinea pigs. Their effects were compared to those induced by milrinone in both atria preparations. Compound 28 (4- benzyl-2-(dimethylamino)-5-pyrimidinecarboxylic acid) was the most effective positive inotropic agent, while the corresponding methyl ester 17 reduced both the contractile force and the frequency of guinea pig atria. An antagonism toward the negative influence exerted by endogenous adenosine on the heart seems to be involved in the contractile activity of compound 28. By contrast, compound 17 might be partial agonist at the purinergic inhibitory (A1) receptor. X-ray analysis carried out on 17 and 28 and molecular modeling investigations extended also to related derivatives allowed a possible rationalization between structure and inotropic activity for this series of compounds.

1,2-Dithiole derivatives

1,2-Dithiole derivatives of the formula: STR1 WHEREIN Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R1 --C(OH)-- in which R1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.