64230-02-0Relevant academic research and scientific papers
THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
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Page/Page column 99; 100, (2019/01/17)
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an anim
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors
Padilla, Fernando,Bhagirath, Niala,Chen, Shaoqing,Chiao, Eric,Goldstein, David M.,Hermann, Johannes C.,Hsu, Jonathan,Kennedy-Smith, Joshua J.,Kuglstatter, Andreas,Liao, Cheng,Liu, Wenjian,Lowrie, Lee E.,Luk, Kin Chun,Lynch, Stephen M.,Menke, John,Niu, Linghao,Owens, Timothy D.,O-Yang, Counde,Railkar, Aruna,Schoenfeld, Ryan C.,Slade, Michelle,Steiner, Sandra,Tan, Yun-Chou,Villase?or, Armando G.,Wang, Ce,Wanner, Jutta,Xie, Wenwei,Xu, Daigen,Zhang, Xiaohu,Zhou, Mingyan,Lucas, Matthew C.
supporting information, p. 1677 - 1692 (2013/04/10)
We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood potencies. Ultimately, our mouse model revealed unexpected toxicity that precluded us from further advancing this series.
PYRROLOPYRAZINE KINASE INHIBITORS
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Page/Page column 80, (2013/03/28)
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF
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Page/Page column 52, (2010/04/03)
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
Processes To Make Apoptosis Promoters
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Page/Page column 31, (2009/12/28)
Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
The synthesis of functionalised hydroazulenes: a new acess to the lactarane skeleton
Tochtermann,Bruhn,Meints,Wolff
, p. 9657 - 9670 (2007/10/02)
An efficient regioselective and stereoselective approach to the hydroazulenic skeleton of the lactarane sesquiterpenes is described. The furan 1 is transformed to the key intermediate 4. Regioselective intramolecular aldol reaction of 4 leads to the hydro
Annulation of α-Formyl α,β-Unsaturated Ketones by a Michael Addition-Cyclization Sequence. A Versatile Synthesis of Alicyclic Six-Membered Rings.
Meyer, Walter L.,Brannon, Michael J.,Burgos, Celmira da G.,Goodwin, Thomas E.,Howard, Ralph W.
, p. 438 - 447 (2007/10/02)
The potential generality of the annulation sequence shown in Scheme II (10 -> 11 -> 12 -> 13 -> 14/15) has been examined in model systems.Dehydrogenation of α-formylcyclohexanones 11a-d with 1 equiv of DDQ rapidly produces α,β-unsaturated α-formyl ketones
