642441-60-9Relevant academic research and scientific papers
Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes
Huang, Jinfeng,Jia, Yimin,Li, Xiangyu,Duan, Jianli,Jiang, Zhong-Xing,Yang, Zhigang
, p. 2314 - 2319 (2021)
A highly regioselective copper-catalyzed 1,4-chloro- and bromotrifluoromethylation of 1,3-enynes has been presented for the first time, which affords an efficient transformation to access halo- and CF3-containing tetrasubstituted allene derivatives with good to excellent yield. This protocol is practical and convenient, in which a wide range of functional groups are compatible. Applications of this method for the gram-scale preparation and late-stage functionalization of biologically active molecules are also demonstrated.
Efficient catalytic transition-metal-free conditions for nucleophilic addition of arylacetylenes to aromatic ketones
Liu, Junfeng,Lin, Jin,Song, Ling
supporting information; experimental part, p. 2160 - 2163 (2012/05/05)
A mild, efficient, and transition-metal-free method for nucleophilic addition of arylacetylenes to diverse aromatic ketones, using catalytic amount of tetrabutylammonium chloride as a promoter and solid KOH as a base in THF, was developed to afford aromat
