642444-30-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(3-TRIFLUOROMETHOXYPHENYL)ETHANOL is used as a pain reliever for the management of moderate to severe pain. It operates by binding to opioid receptors in the brain and spinal cord, effectively inhibiting the transmission of pain signals. The trifluoromethoxy group in its structure plays a crucial role in enhancing the compound's affinity for these receptors, which contributes to its potent analgesic effects.
As a Central Nervous System Depressant:
2-(3-TRIFLUOROMETHOXYPHENYL)ETHANOL is also utilized as a central nervous system depressant, which can help in alleviating anxiety and inducing a calming effect. However, its use in this context must be carefully managed due to the potential side effects such as dizziness, nausea, and respiratory depression.
Controlled Substance:
Due to its potential for abuse and addiction, 2-(3-TRIFLUOROMETHOXYPHENYL)ETHANOL, or Tramadol, is classified as a controlled substance in many countries. This classification is intended to regulate its distribution and use, ensuring that it is prescribed and administered responsibly to minimize the risk of dependency and misuse.
Check Digit Verification of cas no
The CAS Registry Mumber 642444-30-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,2,4,4 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 642444-30:
(8*6)+(7*4)+(6*2)+(5*4)+(4*4)+(3*4)+(2*3)+(1*0)=142
142 % 10 = 2
So 642444-30-2 is a valid CAS Registry Number.
642444-30-2Relevant academic research and scientific papers
2-, 3-, and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds
Castagnetti, Eva,Schlosser, Manfred
, p. 691 - 695 (2007/10/03)
Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3- and 4-isomers can readily be generated from the corresponding 3- and 4-bromo precursors by halogen-metal interconversion with butyllithium or tertbutyllithium. Upon trapping of the 2-, 3- and 4-(trifluoromethoxy)phenyllithiums with 11 different electrophiles the expected products were formed in generally high yields. Only the attempted nucleophilic addition of 2-(trifluoromethoxy)phenyllithium to oxirane did not succeed. This failure is tentatively attributed to a lowering of the nucleophilicity by fluorine-lithium interactions. Conformationally restricted analogs - i.e., 2,2-difluoro-1,3-benzodioxol-4-phenyllithium and its 5-fluoro- and 5-bromo-substituted congeners - did indeed react smoothly with oxirane, affording the adducts in ordinary yields.
