64245-89-2

Upstream product

• 57943-83-6 clavulanic acid p-nitrobenzyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 93680-55-8 (Z)-5-Methoxy-3-{(R)-1-[(4-nitro-benzyloxycarbonyl)-(triphenyl-λ⁵-phosphanylidene)-methyl]-4-oxo-azetidin-2-yloxy}-2-oxo-pent-3-enoic acid 4-nitro-benzyl ester 
• 93680-54-7 (Z)-3-{(R)-1-[Chloro-(4-nitro-benzyloxycarbonyl)-methyl]-4-oxo-azetidin-2-yloxy}-5-methoxy-2-oxo-pent-3-enoic acid 4-nitro-benzyl ester 
• 93697-99-5 (Z)-3-{(R)-1-[Hydroxy-(4-nitro-benzyloxycarbonyl)-methyl]-4-oxo-azetidin-2-yloxy}-5-methoxy-2-oxo-pent-3-enoic acid 4-nitro-benzyl ester 
• 93680-53-6 4-nitrobenzyl (Z)-(6R)-3-(4-nitrobenzyloxycarbonyl)-2-(2-methoxyethylidene)-1-oxaceph-3-em-4-carboxylate 
• 93680-51-4 4-nitrobenzyl 3-hydroxy-9-O-methylclavulanate 

Relevant academic research and scientific papers

Nuclear Modification of Clavulanic Acid. Preparation of Optically Active 1-Oxaceph-3-ems

Lithium (Z)-(6R)-3-benzyloxycarbonyl-2-(2-methoxyethylidene)-1-oxaceph-3-em-4-carboxylate and lithium (Z)-(6R)-2-(2-methoxyethylidene)-1-oxaceph-3-em-4-carboxylate have been prepared from clavulanic acid by way of an intramolecular Wittig reaction.Also fr