642457-77-0Relevant academic research and scientific papers
Synthesis and biological activity of novel S-Adenosyl-L-homocysteine hydrolase inhibitors
Steere, Jennifer A.,Honek, John F.
, p. 3229 - 3236 (2003)
Four potential S-adenosyl-L-homocysteine hydrolase inhibitors were prepared and tested against purified recombinant rat liver enzyme. Preliminary studies indicate that three of these compounds, 1, 2, and 4, caused time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase but showed a biphasic nature. Compound 3 was found to be a rapid equilibrium inhibitor of this enzyme.
