64258-96-4Relevant academic research and scientific papers
Novel functionalized melamine-based nitroheterocycles: Synthesis and activity against trypanosomatid parasites
Baliani, Alessandro,Peal, Valerie,Gros, Ludovic,Brun, Reto,Kaiser, Marcel,Barrett, Michael P.,Gilbert, Ian H.
experimental part, p. 1154 - 1166 (2009/05/30)
Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selective uptake of toxic compounds into trypanosomes has been achieved by exploiting plasma membrane transporters. For example, the P2 aminopurine transporter, along with other transporters, selectively concentrates melamine and benzamidine moieties into trypanosomes. We have previously reported the use of the melamine motif to selectively target nitrofuran to the trypanosome. In this paper we report the further investigation of the structure activity relationships and the effect of the introduction of different functionalized substituents onto the melamine unit. Most of the compounds tested in vitro for their trypanocidal activity showed activities in the submicromolar range against T. b. rhodesiense. The Royal Society of Chemistry 2009.
ROTATIONAL ISOMERS OF THE RADICAL-ANIONS OF 2-CARBONYL-CONTAINING DERIVATIVES OF 5-NITROFURAN
Gavar, R. A.,Baumane, L. Kh.,Stradyn',Ya. P.,Fleischer, M. B.,Chernaeva, M.,Kovach, Ya.
, p. 8 - 15 (2007/10/02)
The radical-anions of 2-carbonyl-containing derivatives of 5-nitrofuran were obtained by electrochemical generation.Their ESR spectra indicate the existence of a mixture of O,O-cis and O,O-trans rotational isomers.The parameters of the isomers were identified by INDO calculations.The more polar form (the cis isomer) is more stable in polar media.
