64260-96-4Relevant articles and documents
Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers
Arrata, Irene,Barnard, Anna,Tomlinson, Darren C.,Wilson, Andrew J.
supporting information, p. 2834 - 2837 (2017/03/11)
Selection methods are used to identify Affimers that recognise α-helix mimicking N-alkylated aromatic oligoamides thus demonstrating foldamer and natural α-amino acid codes are compatible.
Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics
Long, Kérya,Edwards, Thomas A.,Wilson, Andrew J.
, p. 4034 - 4040 (2013/07/27)
Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.
