64262-08-4

Basic information

• Product Name: Quinoxaline, 2,3-bis(4-methyl-1-piperazinyl)-6-nitro-
• Synonyms: Quinoxaline, 2,3-bis(4-methyl-1-piperazinyl)-6-nitro-
• CAS NO: 64262-08-4
• Molecular Formula: C18H25 N7 O2
• Molecular Weight: 371.44
• Mol File: 64262-08-4.mol

Chemical Properties

• Melting Point: 216-218 °C
• Boiling Point: 553.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.287±0.06 g/cm3(Predicted)
• PKA: 6.71±0.42(Predicted)
• CAS DataBase Reference: Quinoxaline, 2,3-bis(4-methyl-1-piperazinyl)-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 2,3-bis(4-methyl-1-piperazinyl)-6-nitro-(64262-08-4)
• EPA Substance Registry System: Quinoxaline, 2,3-bis(4-methyl-1-piperazinyl)-6-nitro-(64262-08-4)

Safety Data

• Hazardous Substances Data: 64262-08-4(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 2379-60-4 2,3-dichloro-6-nitroquinoxaline 

Downstream Products

• 64262-21-1 N-[2,3-bis-(4-methyl-piperazin-1-yl)-quinoxalin-6-yl]-toluene-4-sulfonamide 

Relevant articles and documents

Displacement Reactions of 2,3-Dichloro-6-nitroquinoxaline: Synthesis of s-Triazoloquinoxaline

2,3-Dichloro-6-nitroquinoxaline (1) undergoes displacement reactions with 1-methylpiperazine in the hot to give the bis-derivative (2) and at 30 deg C selectively at position-2 to afford the mono-derivative (3).Structure-proof for the latter involves transformation of 3 through hydrazine derivative (4) to the triazoloquinoxaline (5) and its 1-phenyl derivative (6) and comparison of the chemical shifts of protons at C-9 in the pair.

Antiamebic amidines and sulfonamides of 5- and 6-amino-2,3-bis(4-alkyl-1-piperazinyl)quinoxalines

A series of amidines and sulfonamides of 5- and 6-amino-2,3-bis(4-alkyl-1-piperazinyl)quinoxalines was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. Four compounds (5, 6, 8,

2,3-Bis(4-alkyl-1-piperazinyl)quinoxalines

This disclosure describes compounds of the class of 5- or 6-substituted 2,3-bis(4-alkyl-1-piperazinyl)quinoxalines useful for ameliorating cecal and hepatic amebic infestations in warm-blooded animals.