64262-23-3

Basic information

• Product Name: 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE
• Synonyms: N-PROPYLPIPERAZINE DIHYDROBROMIDE;1-N-PROPYLPIPERAZINE DIHYDROBROMIDE;1-N-PROPYLPIPERAZINE HYDROBROMIDE;1-PROPYLPIPERAZINE DIHYDROBROMIDE;N-propylpiperazinium dibromide;1-n-Propylpiperazine dihydrobromide,99%;1-(1-Propyl)piperazine dihydrobromide;1-n-Propylpiperazine 2HBr
• CAS NO: 64262-23-3
• Molecular Formula: 2BrH*C₇H₁₆N₂
• Molecular Weight: 290.04
• EINECS: 264-759-1
• Product Categories: Nitrogen cyclic compounds;Building Blocks;Heterocyclic Building Blocks;Piperazines;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 64262-23-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 259.5-264.5 °C(lit.)
• Boiling Point: 176.7 °C at 760 mmHg
• Flash Point: 60.7 °C
• Appearance: slightly yellow to light beige crystalline powder
• Vapor Pressure: 1.08mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: water: soluble50mg/mL, clear, colorless
• Sensitive: Hygroscopic
• BRN: 3678528
• CAS DataBase Reference: 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE(64262-23-3)
• EPA Substance Registry System: 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE(64262-23-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 64262-23-3(Hazardous Substances Data)

Usage

Uses

1-n-Propylpiperazine dihydrobromide was used in the synthesis of amidines and sulfonamides of 5-and 6-amino-2,3-bis(4-alkyl-1-piperazazinyl)quinoxalines.

General Description

1-n-Propylpiperazine dihydrobromide reacts with potassium thiocyanate to yield 1-(4-n-propyl)piperazine thioamide.

InChI:InChI=1S/C7H16N2.2BrH/c1-2-5-9-6-3-8-4-7-9;;/h8H,2-7H2,1H3;2*1H

Upstream product

• 71172-70-8 4-propyl-piperazine-1-carboxylic acid ethyl ester 

Downstream Products

• 1416401-49-4 C₂₀H₃₀N₄S 

Relevant articles and documents

Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives

We developed new intravenous sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. We synthesized approximately 170 derivatives and evaluated their hypnotic effects by intravenous administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs, 3(-), 5(-), 27(-), and 47(-) [JM-1232(-)], showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, respectively, and the lethal doses (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, respectively. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, respectively. Among these compound, 47(-) [JM-1232(-)] is being considered as the most potential candidate for clinical trials in humans.