64265-63-0Relevant academic research and scientific papers
Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers
Melchiorre, Michele,Del Lungo, Martina,Guandalini, Luca,Martini, Elisabetta,Dei, Silvia,Manetti, Dina,Scapecchi, Serena,Teodori, Elisabetta,Sartiani, Laura,Mugelli, Alessandro,Cerbai, Elisabetta,Romanelli, Maria Novella
supporting information; scheme or table, p. 6773 - 6777 (2010/12/18)
New If blockers have been designed and tested on HEK293 cells stably expressing the HCN1, HCN2, and HCN4 channels to find compounds able to discriminate among the channel isoforms. Among the synthesized compounds, the cis-butene derivative (R)-5 shows some preference for HCN2 while the pseudodimeric product (R)-6 shows selectivity for HCN1. These compounds can be important pharmacological tools to study the channels in native tissues and may be useful to design safe drugs.
Effect of β-Alkyl Substitution on D-1 Dopamine Agonist Activity: Absolute Configuration of β-Methyldopamine
Riggs, Robert M.,McKenzie, Ann T.,Byrn, Stephen R.,Nichols, David E.,Foreman, Mark M.,Truex, Lewis L.
, p. 1914 - 1918 (2007/10/02)
β-Methyldopamine and its enantiomers and racemic β-phenyldopamine were synthesized and evaluated for dopamine D-1 agonist activity.In the dopamine-sensitive adenylate cyclase assay, β-phenyldopamine had about one-sixth the activity of dopamine.Racemic β-m
