64266-26-8

Basic information

• Product Name: 1H-Benzimidazole-1-propanenitrile,2-amino-(9CI)
• Synonyms: 1H-Benzimidazole-1-propanenitrile,2-amino-(9CI)
• CAS NO: 64266-26-8
• Molecular Formula: C10H10N4
• Molecular Weight: 186.2132
• Product Categories: BENZIMIDAZOLE
• Mol File: 64266-26-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole-1-propanenitrile,2-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-1-propanenitrile,2-amino-(9CI)(64266-26-8)
• EPA Substance Registry System: 1H-Benzimidazole-1-propanenitrile,2-amino-(9CI)(64266-26-8)

Safety Data

• Hazardous Substances Data: 64266-26-8(Hazardous Substances Data)

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 107-13-1 acrylonitrile 

Relevant articles and documents

The reaction of amino-imidazoles, -pyrazoles and -triazoles with α,β-unsaturated nitriles

The reactions of α,β-unsaturated nitriles (1, 9, 12) as bielectrophiles with aminoazoles (2, 4, 6) as binucleophiles were investigated. Acrylonitrile (1) reacts almost exclusively in a chemoselective Michael-type addition yielding the substituted azoles 3, 5 and 7, respectively. Cinnamonitriles 9a,b behave in a similar way, but the free CN group adds a second molecule 4 yielding 10a,b and its cyclocondensation product 11a,b as minor component. The attempted formation of azolopyrimidines is best achieved by the reaction of the benzylidenemalononitriles 12a - f with 2 or 4. The process is chemo- and regioselective. The structure determinations were based on NMR measurements including DEPT, COSY, ROESY, HMQC and HMBC techniques and correct earlier suggestions.