64268-93-5

Basic information

• Product Name: 1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE
• Synonyms: 1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE;1-[(4-nitrophenyl)sulphonyl]piperidine;N-(4-NITROPHENYLSULFONYL)PIPERIDINE
• CAS NO: 64268-93-5
• Molecular Formula: C₁₁H₁₄N₂O₄S
• Molecular Weight: 270.3
• Mol File: 64268-93-5.mol
• Article Data: 14

Chemical Properties

• Melting Point: 166 °C
• Boiling Point: 435.9 °C at 760 mmHg
• Flash Point: 217.4 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 8.43E-08mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE(64268-93-5)
• EPA Substance Registry System: 1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE(64268-93-5)

Safety Data

• Hazardous Substances Data: 64268-93-5(Hazardous Substances Data)

Usage

General Description

The chemical 1-[(4-nitrophenyl)sulfonyl]piperidine, also known as NPSPI, is a sulfonamide compound with the molecular formula C11H14N2O4S. It is a white to off-white crystalline powder that is sparingly soluble in water and soluble in organic solvents. NPSPI is widely used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been found to exhibit anti-inflammatory and analgesic properties, making it a promising candidate for drug development. Additionally, NPSPI has been studied for its potential use as a corrosion inhibitor in metalworking and industrial applications. Overall, 1-[(4-nitrophenyl)sulfonyl]piperidine is a versatile compound with diverse applications in the fields of medicine, agriculture, and materials science.

InChI:InChI=1/C11H14N2O4S/c14-13(15)10-4-6-11(7-5-10)18(16,17)12-8-2-1-3-9-12/h4-7H,1-3,8-9H2

Upstream product

• 110-89-4 piperidine 
• 155164-61-7 2-(4-nitrobenzenesulfonyl)-4,5-dichloropyridazin-3-one 
• 156840-00-5 2,4-dinitrophenyl 4-nitrobenzenesulfonate 
• 30362-87-9 p-Nitrophenyl p-nitrobenzenesulphonate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 1441409-91-1 (E)-ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate 
• 111-29-5 1 ,5-pentanediol 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 173778-68-2 1,5-pentanediyl bis(diphenylphosphinite) 

Downstream Products

• 952-97-6 4-nitrophenyl phenyl sulfide 
• 6336-68-1 4-(piperidin-1-ylsulfonyl)aniline 
• 790691-27-9 N-[4-(isocyanato)phenylsulfonyl]piperidine 
• 1601403-39-7 3-oxo-N-(4-(piperidin-1-ylsulfonyl)phenyl)benzo[d]isothiazole-2(3H)-carboxamide 

Relevant articles and documents

Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents

Arylsulfonamides bearing (aza)norbornane and related motifs were evaluated for: (1) antimicrobial activity toward five key ESKAPE pathogenic bacteria, one Gram‐positive bacteria methicillin‐resistant Staphylococcus aureus (MRSA, ATCC 43300), four Gram‐neg

VACCINE ADJUVANT

Compounds useful as an adjuvant, e.g., formulas (I)-(VI) and uses thereof, for example, with immunogenic moieties or other adjuvants, are provided.

1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors

A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 = 1.15 nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site.