64269-81-4Relevant academic research and scientific papers
Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands
Ravera, Mauro,Gabano, Elisabetta,Sardi, Manuele,Ermondi, Giuseppe,Caron, Giulia,McGlinchey, Michael J.,Müller-Bunz, Helge,Monti, Elena,Gariboldi, Marzia B.,Osella, Domenico
, p. 400 - 409 (2011)
The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2- yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity.
Intramolecular Imidazole-Promoted General-Base Catalysis of the Hydrolysis of an Acetylimidazole
Brown, R.S.,Clewley, R.G
, p. 1216 - 1218 (2007/10/02)
Intramolecular general-base catalysis of the hydrolysis of an acetylimidazole by imidazole is assessed by studying the hydrolysis of 2-(imidazol-2-ylmethyl)-N-acetylimidazole (3).The pH vs. log kobsd profile exhibits three major domains that consist of H2O attack on the protonated acetylimidazolium unit,OH- attack on the neutral material, and an intramolecular general-base catalysis of H2O on the neutral species.Consistent with the latter is a plateau observed in the pH profile (k3 = 1.02*10-3 s-1) at neutrality and a solvent kinetic isotope effect of kH2O/kD2O = 2.8 in that region.The effective molarity of the intramolecular imidazole in 3 can be assessed by comparing the value of k3 with the second-order rate constant for 2-methylimidazole catalyzing the hydrolysis of 2-methyl-N-acetylimidazole (4).After the difference in the imidazole pKa values is corrected for, the effective molarity of the intramolecular catalyst is 3 M.
