64297-92-3

Basic information

• Product Name: 2-BROMO-N-PHENETHYL-ACETAMIDE
• Synonyms: CHEMBRDG-BB 4023661;2-BROMO-N-PHENETHYL-ACETAMIDE;AKOS BB/0099;2-BROMO-N-(2-PHENYLETHYL)ACETAMIDE;AKOS BBB/451;2-bromo-N-(2-phenylethyl)acetamide(SALTDATA: FREE)
• CAS NO: 64297-92-3
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Mol File: 64297-92-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 391.241°C at 760 mmHg
• Flash Point: 190.416°C
• Appearance: /
• Density: 1.388g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 2-BROMO-N-PHENETHYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N-PHENETHYL-ACETAMIDE(64297-92-3)
• EPA Substance Registry System: 2-BROMO-N-PHENETHYL-ACETAMIDE(64297-92-3)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 64297-92-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12BrNO/c11-8-10(13)12-7-6-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)

Upstream product

• 64-04-0 phenethylamine 
• 598-21-0 2-Bromoacetyl bromide 
• 13156-95-1 2-chloro-N-phenethylacetamide 
• 79-08-3 bromoacetic acid 
• 22118-09-8 2-bromoacetyl chloride 

Downstream Products

• 1370607-42-3 NSC 742956 
• 919435-02-2 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide 

Relevant articles and documents

The mckenna reaction – avoiding side reactions in phosphonate deprotection

The McKenna reaction is a well-known and popular method for the efficient and mild synthesis of organophosphorus acids. Bromotrimethylsilane (BTMS) is the main reagent in this reaction, which transforms dialkyl phosphonate esters into bis(trimethylsilyl)esters, which are then easily converted into the target acids. However, the versatile character of the McKenna reaction is not always used to its full extent, due to formation of side products. Herein, demonstrated by using model examples we have not only analyzed the typical side processes accompanying the McKenna reaction, but also uncovered new ones. Further, we discovered that some commonly recommended precautions did not always circumvent the side reactions. The proposed results and recommendations may facilitate the synthesis of phosphonic acids.

New indole based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents

Current study is based on the sequential conversion of indolyl butanoic acid (1) into ethyl indolyl butanoate (2), indolyl butanohydrazide (3), and 1,3,4-oxadiazole-2-thiol analogs (4) by adopting chemical transformations. In a parallel series of reaction

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc 1 inhibitors

A previous phenotypic screen by GSK identified 2-(quinolin-4-yloxy)acetamides as potent growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary structure-activity relationship (SAR) study of the compound class which has yielded more potent inhibitors. An Mtb cytochrome bd oxidase deletion mutant (cydKO) was found to be hypersensitive to most members of the compound library, while strains carrying single-nucleotide polymorphisms of the qcrB gene, which encodes a subunit of the menaquinol cytochrome c oxidoreductase (bc1) complex, were resistant to the library. These results identify that the 2-(quinolin-4-yloxy)acetamide class of Mtb growth inhibitors can be added to the growing number of scaffolds that target the M. tuberculosis bc1 complex.