643-29-8

Upstream product

• 97915-94-1 (1aR)-1,1,3a-trimethyl-(1ar,3ac,7at,7bc)-decahydro-cyclopropa[a]naphthalen-7-one 
• 527-90-2 (1aR,3aS,7S,7aS,7bR)-1,1,3a,7-tetramethyldecahydro-1H-cyclopropa[a]naphthalen-7-ol 
• 97915-93-0 Trimethyl-((1aR,3aS,7S,7aS,7bR)-1,1,3a,7-tetramethyl-decahydro-cyclopropa[a]naphthalen-7-yl)-ammonium; hydroxide 
• 885459-78-9 (1aR)-7t-acetoxy-1,1,3a,7c-tetramethyl-(1ar,3ac,7at,7bc)-decahydro-cyclopropa[a]naphthalene 

Downstream Products

• 489-27-0 Epimaaliol 

Relevant academic research and scientific papers

Isogermacrene A, a proposed intermediate in sesquiterpene biosynthesis

A sesquiterpene hydrocarbon, isogermacrene A (5), which is structurally related to the gorgonanes and zieranes, was isolated from the essential oil of Saccogyna viticulosa (Hepaticae). This monocyclic compound is proposed as the biogenetic intermediate of some rare sequiterpene skeletons. In the essential oil of the liverwort Saccogyna viticulosa, collected on the island of Madeira, the new sesquiterpene hydrocarbons isogermacrene A (5) and its Cope rearrangement product iso-β-elemene (6) were identified. 5 is proposed to act as the biogenetic precursor of several new sesquiterpenes identified in the volatiles of S. viticulosa. These include iso-α-humulene, α-gorgonene, gorgona-1,4(15),11-triene and gorgon-11-en-4-ol. In addition, the Cope product of zierene, isozierene, allo-aromadendra-4(15),10(14)-diene, aromadendra-4(15),10(14)-dien-1-ol and a prenylguaiane diterpene alcohol, named viticulol, were identified as new natural products.

Metabolites from the Marine Sponge Epipolasis kushimotoensis

Two isothiocyanates,epipolasin-A 1 and -B 2,and two corresponding thiourea derivatives,epipolasinthiourea-A 14 and -B 15, were isolated from the marine sponge E.kushimotoensis.Their structures were elucidated on the basis of chemical and spectral evidence.The thioureas 14 and 15 showed cell growth inhibition activity.Keywords-sponge;Epipolasis kushimotoensis;epipolasin-A,-B; epipolasinthiourea-A, -B; sesquiterpene; isothiocyanate; thiourea derivative; cell growth inhibition