643014-01-1

Basic information

• Product Name: methyl (2S)-5-[(2S)-1-benzyl-2-tert-butoxycarbonyl-5-pyrrolidinylidenyl]-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate
• Synonyms: methyl (2S)-5-[(2S)-1-benzyl-2-tert-butoxycarbonyl-5-pyrrolidinylidenyl]-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate
• CAS NO: 643014-01-1
• Molecular Weight: 498.499
• Mol File: 643014-01-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (2S)-5-[(2S)-1-benzyl-2-tert-butoxycarbonyl-5-pyrrolidinylidenyl]-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S)-5-[(2S)-1-benzyl-2-tert-butoxycarbonyl-5-pyrrolidinylidenyl]-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate(643014-01-1)
• EPA Substance Registry System: methyl (2S)-5-[(2S)-1-benzyl-2-tert-butoxycarbonyl-5-pyrrolidinylidenyl]-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate(643014-01-1)

Safety Data

• Hazardous Substances Data: 643014-01-1(Hazardous Substances Data)

Upstream product

• 88668-76-2 methyl (2S)-5-diazo-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate 
• 90741-27-8 (S)-tert-butyl 1-benzyl-5-oxopyrrolidine-2-carboxylate 
• 35418-16-7 L-t-butyl pyroglutamate 
• 90741-31-4 (S)-N-benzyl-5-thioxoproline tert-butyl ester 
• 161553-09-9 methyl (2S)-5-bromo-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate 
• 831242-10-5 methyl (2S)-5-chloro-4-oxo-2-(2,2,2-trifluoroacetamido)-pentanoate 

Downstream Products

• 643014-12-4 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-((2S)-2-((2S)-2-(9H)-fluoren-9-ylmethoxycarbonylamino-4-methylpentanamido)-4-tert-butoxycarbonylpropanamido)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-14-6 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-((2S)-2-((2S)-2-(2-benzyloxycarbonylaminoacetamido)-4-methylpentanamido)-4-tert-butoxycarbonylpropanamido)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-10-2 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-((2S)-2-(9H)-fluoren-9-ylmethoxycarbonylamino-4-tert-butoxycarbonylpropanamido)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-13-5 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-((2S)-2-((2S)-2-amino-4-methylpentanamido)-4-tert-butoxycarbonylpropanamido)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-08-8 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-(fluoren-9-ylmethoxycarbonylamino)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-11-3 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-((2S)-2-amino-4-tert-butoxycarbonylpropanamido)-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 
• 643014-09-9 diphenylmethyl (3S,6S,9aS)-6-[(2S)-2-amino-3-methylbutanamido]-5-oxo-octahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 

Relevant articles and documents

Synthesis of an external β-turn based on the GLDV motif of cell adhesion proteins

The (3S,6S,10S)-7/5 bicyclic lactam 4, designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser condensation. Calculated preferred conformations compare well with the preferred solid state conformation,