64302-63-2Relevant academic research and scientific papers
Microwave synthesis and anticonvulsant activity of new 3-benzyl-1,2,3- benzotriazin-4(3H)-ones
Kornet
, p. 1391 - 1393 (2007/10/03)
Several 3-benzyl-1,2,3-benzotriazin-4(3H)-ones 1 were prepared by alkylation of 1,2,3-benzotriazin-4(3H)-one with benzyl halides in dimethylformamide in a microwave oven in moderate yields. Accompanying 1 were minor amounts of products believed to be the O-alkylated derivatives. Support for 3-benzylation is shown by an alternate synthesis of 1a from o-amino-N- benzylbenzamide by nitrous acid cyclization. The title compounds were evaluated in mice and rats in maximal electroshock (MES) and pentylenetetrazole (scMet) seizure models for anticonvulsant activity, and in the rotorod test for neurotoxicity. They were generally non-toxic. The 3- benzyl analog was the most active (maximal electroshock) compound; it's maximal electroshock ED50 value was 93 mg/kg (mouse).
