643022-65-5

Upstream product

• 643022-62-2 Acetic acid (4R,5S)-4-(4-nitro-phenyl)-2-oxo-oxazolidin-5-yl ester 
• 643022-59-7 (4R,5S)-5-Acetyl-4-(4-nitro-phenyl)-oxazolidin-2-one 

Relevant academic research and scientific papers

Highly Enantioselective Synthesis of 1,2-Amino Alcohol Derivatives via Proline-Catalyzed Mannich Reaction

Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation.