64308-51-6

Basic information

• Product Name: N-(morpholin-4-yl)-4-nitrobenzenesulfonamide
• Synonyms: benzenesulfonamide, N-4-morpholinyl-4-nitro-
• CAS NO: 64308-51-6
• Molecular Formula: C₁₀H₁₃N₃O₅S
• Molecular Weight: 287.2923
• Mol File: 64308-51-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 472.9°C at 760 mmHg
• Flash Point: 239.8°C
• Density: 1.52g/cm³
• Vapor Pressure: 4.13E-09mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: N-(morpholin-4-yl)-4-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(morpholin-4-yl)-4-nitrobenzenesulfonamide(64308-51-6)
• EPA Substance Registry System: N-(morpholin-4-yl)-4-nitrobenzenesulfonamide(64308-51-6)

Safety Data

• Hazardous Substances Data: 64308-51-6(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 4319-49-7 1-aminomorpholine 
• 10125-39-0 3,3-diethyl-1-(4-nitrophenyl)triaz-1-ene 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Relevant articles and documents

Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source

Various sulfonamides have been synthesized from triazenes and sulfur dioxide. In the presence of just a catalytic amount of BF3· OEt2, a series of 1-aryl-triazenes were converted into sulfonyl hydrazines in good to excellent yields. When using CuCl2 as the catalyst, the corresponding sulfonamides can be produced from the 1-aryl triazenes in good yields. This journal is the Partner Organisations 2014.

Reactions of benzenesulfonohydrazides and benzenesulfonamides with hydrogen chloride or hydrogen bromide in acetic acid

Benzenesulfonohydrazides capable of yielding a sulfinic acid intermediate by virtue of a basic nitrogen atom in the second position of the hydrazide moiety produced thiosulfonates when treated with 1 N hydrogen chloride in acetic acid and produced disulfides when treated with 1 N hydrogen bromide in the same solvent. In two cases, a crystalline mixture of p-nitrophenyl p-nitrobenzenethiosulfonate and bis(p-nitrophenyl) disulfide was isolated from the hydrogen chloride reactions. No reaction product was obtained from either the hydrogen chloride or hydrogen bromide reaction with benzenesulfonohydrazides that were unable to form a sulfinic acid intermediate. Reduction of benzenesulfonamides to disulfides appeared to be possible only with hydrogen bromide in acetic acid. No thiosulfonate was isolated from the treatments of benzenesulfonamides with 1 N hydrogen chloride in acetic acid. p-Nitrophenyl p-nitrobenzenethiosulfonate and p-bromophenyl p-bromobenzenethiosulfonate exhibited some antimicrobial activities against Gram-positive bacteria. The latter compound also showed analgesic properties in the phenylquinone test.