64318-28-1Relevant articles and documents
Tyramine fragment binding to BACE-1
Kuglstatter, Andreas,Stahl, Martin,Peters, Jens-Uwe,Huber, Walter,Stihle, Martine,Schlatter, Daniel,Benz, Joerg,Ruf, Armin,Roth, Doris,Enderle, Thilo,Hennig, Michael
, p. 1304 - 1307 (2008)
Fragment screening revealed that tyramine binds to the active site of the Alzheimer's disease drug target BACE-1. Hit expansion by selection of compounds from the Roche compound library identified tyramine derivatives with improved binding affinities as m
Investigation on the synthesis of new 3-[4-(Arylalkoxy)phenylethyl]-2-thioxo-1,3-thiazolidin-4-ones and their biological evaluation against cancer cells
Dago, Camille Déliko,N’ta Ambeu, Christelle,Coulibaly, Wacothon Karime,Békro, Yves-Alain,Mamyrbekova-Bekro, Janat A.,Le Guével, Rémy,Corlu, Anne,Bazureau, Jean-Pierre
, p. 341 - 349 (2017)
(Figure Presented) Herein, we report on the 5-step synthesis of new 3-[4-(arylalkoxy)phenylethyl]-2-thioxo-1,3-thiazolidin-4-ones without 5-arylidene fragments starting from tyramine The construction involved protection with Boc2O, regioselective O-alkyla
Bactericidal compound based on exogenous metabolite of xanthomonas, and preparation method and application of bactericidal compound
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Paragraph 0076-0080, (2021/07/14)
The invention discloses a bactericidal compound based on an exogenous metabolite of xanthomonas and a preparation method and application of the bactericidal compound. The bactericidal compound is a compound MB or a compound DB. The structural formulas of the compound MB and the compound DB are as shown in the specification. According to the invention, in order to solve the technical problems that an existing broad-spectrum bactericide generates membrane resistance and is difficult to pass through a cell membrane, a whole genome metabolic network model of xanthomonas is established, a specific exogenous metabolite tyramine of xanthomonas is screened and identified, and tyramine and an existing bactericide, namely luteolin or isoprothiolane are spliced respectively to synthesize the compound MB or the compound DB. The two compounds can specifically inhibit growth of xanthomonas, so the problem that a broad-spectrum bactericide generates membrane resistance is effectively solved, an inhibition rate is remarkably increased, the dosage of the bactericide is effectively reduced. The method is low in cost and high in efficiency, and has wide application prospects and economic values.
COMPOSITION AND METHODS FOR TUMOR IMAGING AND TREATMENT
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Paragraph 0125, (2021/11/13)
Radioisotope-labeled small molecule activity-based probes that target the cancer associated serine hydrolase neutral cholesterol ester hydrolase 1 (NCEH1) are described. The probes can undergo a reaction with the NCEH1, resulting in covalent bonding of a