64319-84-2

Usage

Structure

It is a derivative of quinolin with an amino group and a hydroxyl group attached to a quinoline ring, with a chlorine atom at the 6th position.

Pharmaceutical Potential

Being studied for antimicrobial and antimalarial properties.

Medical Applications

Investigated for the development of new drugs for various medical conditions.

Material Science

Investigated for potential applications in the development of new materials.

Synthetic Chemistry

Used as a building block for the synthesis of other organic compounds.

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1136479-34-9 4-Bromo-6-chloro-quinolin-2-ylamine 

Relevant academic research and scientific papers

Process for making 2-amino-4-hydroxyquinolines

The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-α,α-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

2-Amino-3-cyano-4-hydroxyquinolines

The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxyquinolines and 2-amino-α,α-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.