64323-65-5Relevant articles and documents
Iminodimethylation, a method for a pharmacomodulation in the pyrimido-[3,4-a]-s-triazine series
Menager,Loire,Petrakian,Combet Farnoux,Delabos,Garnier,Lafont
, p. 29 - 37 (2007/10/02)
Primary amines react with two formaldehydes and compounds presenting two mobile hydrogen atoms, this reaction can be called iminodimethylation. This reaction can be used in order to perform a pharmacomodulation in the pyrimido [3,4-a]-s-triazine series. Against Epidermophyton floccosum, the activity is better when nitrogen 7 is not substituted, when the heroatom in position 2 is 0 instead of S and when an aromatic nucleus is directly linked to the nitrogen atom in position 3.