64328-62-7Relevant academic research and scientific papers
1-substituted benzoyl-4-fatty acyl semicarbazide derivative, preparation method and application thereof as antibacterial agent
-
Paragraph 0108; 0109; 0111; 0211; 0214, (2018/09/14)
The invention belongs to the technical field of antibacterial agents, and relates to a 1-substituted benzoyl-4-fatty acyl semicarbazide derivative, a preparation method and application thereof as an antibacterial agent. The compound is shown in a formula
Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones
Zhu, Zi-Shi,Wang, Shi-Ben,Deng, Xian-Qing,Liu, Da-Chuan,Quan, Zhe-Shan
, p. 628 - 635 (2014/05/20)
A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.
Synthesis and gelation behavior of 4′-propyl-1,1′- bi(cyclohexyl)-4-one 4-alkoxybenzoylhydrazone
Li, Juan,Chen, Pei,Chen, Xinbing,An, Zhongwei,Li, Yan
scheme or table, p. 1329 - 1330 (2011/02/17)
A series of new alkoxybenzoylhydrazones of 4′-propyl-1,1′- bi(cyclohexyl)-4-one were prepared as novel low molecular weight organogelators (LMOGs). Their gelation behaviors in 10 solvents were tested. Some of the compounds could form stable gels in bulk o
Synthesis and mesomorphic properties of azo compounds derived from phenyl- and thienyl-1,3,4-thiadiazole
Parra,Villouta,Vera,Belmar,Zú?iga,Zunza
, p. 1533 - 1538 (2007/10/03)
The synthesis and mesomorphic behaviour of new series of liquid crystals containing 1,3,4-thiadiazole and thiophene rings with azo central bond are reported (series 5a and 5b). All compounds of series 5a exhibit enantiotropic nematic mesophase and the hig
