64328-63-8

Basic information

• Product Name: 4-HEXYLOXY-BENZOIC ACID HYDRAZIDE
• Synonyms: Benzoicacid, p-(hexyloxy)-, hydrazide (7CI); 4-(Hexyloxy)benzoic acid hydrazide;4-Hexyloxybenzoylhydrazine
• CAS NO: 64328-63-8
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.32
• Mol File: 64328-63-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 77-80 °C(Solv: methanol (67-56-1))
• Appearance: /
• Density: 1.057g/cm³
• Refractive Index: 1.526
• PKA: 12.69±0.10(Predicted)
• CAS DataBase Reference: 4-HEXYLOXY-BENZOIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HEXYLOXY-BENZOIC ACID HYDRAZIDE(64328-63-8)
• EPA Substance Registry System: 4-HEXYLOXY-BENZOIC ACID HYDRAZIDE(64328-63-8)

Safety Data

• Hazardous Substances Data: 64328-63-8(Hazardous Substances Data)

Usage

Chemical compound

4-HEXYLOXY-BENZOIC ACID HYDRAZIDE

Commonly known as

HOBH

Physical properties

White to off-white crystalline powder with a faint odor

Uses

Coupling agent in peptide synthesis, reagent for preparation of amides, esters, and peptide bonds, photoreactive agent for modification of proteins and peptides

Potential applications

Pharmaceutical and agricultural industries for synthesis of new compounds with biological activity

Precautions

Handle with caution, may cause irritation and is harmful if ingested or inhaled

InChI:InChI=1/C13H20N2O2/c1-2-3-4-5-10-17-12-8-6-11(7-9-12)13(16)15-14/h6-9H,2-5,10,14H2,1H3,(H,15,16)

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 111-25-1 1-bromo-hexane 
• 1142-39-8 para-hexyloxybenzoic acid 
• 544-10-5 1-Chlorohexane 
• 39649-71-3 4-hexyloxybenzoyl chloride 
• 50822-54-3 methyl 4-hexyloxybenzoate 
• 154845-72-4 4-hexyloxy-benzoic acid ethyl ester 

Downstream Products

• 337461-27-5 2-(4-bromophenyl)-5-(4-hexyloxyphenyl)-[1,3,4]oxadiazole 
• 77477-53-3 5,5'-Bis-<4-hexyloxy-phenyl>-2,2'-di-1,3,4-thiadiazol 
• 1630012-58-6 C₁₈H₂₉N₃O₃ 
• 1630013-00-1 4-butyl-5-(4-hexyloxyphenyl)-2H-1,2,4-triazole-3(4H)-one 
• 1630012-44-0 C₁₄H₁₈N₂O₃ 
• 1280728-33-7 C₁₇H₂₄N₂O₂ 
• 876522-84-8 C₂₂H₂₉N₃O₂ 
• 945116-74-5 C₂₂H₂₆N₂O₂ 
• 1280728-32-6 C₁₇H₂₆N₂O₂ 
• 1280728-31-5 C₁₅H₂₂N₂O₂ 
• 876523-18-1 C₂₀H₂₄N₂O₃ 
• 876522-78-0 C₂₁H₂₆N₂O₃ 
• 360568-46-3 C₂₀H₂₄N₂O₂ 
• 179165-09-4 C₂₂H₂₆N₂O₅ 

Relevant articles and documents

1-substituted benzoyl-4-fatty acyl semicarbazide derivative, preparation method and application thereof as antibacterial agent

The invention belongs to the technical field of antibacterial agents, and relates to a 1-substituted benzoyl-4-fatty acyl semicarbazide derivative, a preparation method and application thereof as an antibacterial agent. The compound is shown in a formula

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.

Synthesis and gelation behavior of 4′-propyl-1,1′- bi(cyclohexyl)-4-one 4-alkoxybenzoylhydrazone

A series of new alkoxybenzoylhydrazones of 4′-propyl-1,1′- bi(cyclohexyl)-4-one were prepared as novel low molecular weight organogelators (LMOGs). Their gelation behaviors in 10 solvents were tested. Some of the compounds could form stable gels in bulk o