6435-76-3Relevant academic research and scientific papers
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 72, (2013/08/28)
Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
Cu-catalyzed double S-alkenylation of potassium sulfide: A highly efficient method for the synthesis of various thiophenes
You, Wei,Yan, Xiaoyu,Liao, Qian,Xi, Chanjuan
supporting information; experimental part, p. 3930 - 3933 (2010/11/02)
An efficient synthetic approach to variously substituted thiophenes has been developed through copper-catalyzed tandem S-alkenylation of potassium sulfide with 1,4-diiodo-1,3-dienes.
Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
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, (2008/06/13)
Compounds of the formula STR1 wherein R21 and R22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula STR2 and the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase
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, (2008/06/13)
Compounds of the formula the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
Organosulfur Compounds, L. - 2H-Thiopyrans and Dihydro-2H-thiopyrans, Synthons for Thiophenes
Praefcke, Klaus,Weichsel, Christian
, p. 1604 - 1619 (2007/10/02)
2H-Thiopyran derivatives yield thiophenes on pyrolysis at 240-260 deg C.The influence of substitution in positions 3 to 6 of the 2H-thiopyrans on these new thermal rearrangement and fragmentation reactions is dealt with, and some proposed mechanisms are discussed in detail.A novel three-step synthesis of thiophenes from carbonyl compounds via the corresponding thiones, their -cycloaddition with 1,3-dienes with formation of dihydro-2H-thiopyrans and subsequent thermal conversion is described.In this reaction sequence, whose scope and limitations are outlined, t he thiocarbonyl compound contributes the sulfur and the 1,3-diene the carbon skeleton of the desired thiophenes.
