64354-20-7Relevant academic research and scientific papers
Synthesis and selected reactions of ethyl 5-(1-chloroethyl)-2-methylfuran- 3-carboxylate
Pevzner
, p. 111 - 115 (2008/02/11)
Ethyl 2-methylfuran-3-carboxylate is smoothly chloroethylated at 0°C in the 5 position of the ring. The resulting halide alkylates secondary amines but eliminates HCl with sodium diethyl phosphite under the Michaelis-Becker reaction conditions and with trimethyl phosphite under the Arbuzov reaction conditions. In the reaction with sodium diethyl phosphite, small amounts of 5-[1-(diethoxyphosphoryl)ethyl]furan-3-carboxylate and 5-ethylfuran-3- carboxylate are formed. In the Arbuzov reaction at a 1: 1.22 furan: trimethyl phosphite molar ratio, methyl 2,4-dimethyl-1-methoxy-1-oxo- 1λ5-1,2-dihydrophospheto[3,2-b]furan-5-carboxylate was isolated.
A CONVENIENT APPROACH TO FURAN DERIVATIVES BY I2-INDUCED CYCLISATION OF 2-ALKENYL SUBSTITUTED 1,3-DICARBONYL COMPOUNDS
Antonioletti, R.,Bonadies, F.,Scettri, A.
, p. 4987 - 4990 (2007/10/02)
5-iodoalkyl-4,5-dihydrofurans 2, 5-alkylidene-4,5-dihydrofurans 3 and 2,3,5-trisubstituted furans 4 are obtained through a simple sequence, involving, in the key-step, a regio- and stereoselective iodoenoletherification of 2-alkenyl substituted 1,3-dicarbonyl compounds 1.
Preparation of 3-carboalkoxy or 3-alkanoyl furans
-
, (2008/06/13)
A large group of derivatives of 3-furoic acid and 3-furyl ketones can be prepared in high yield by a process which consists of reacting an α,β-unsaturated ketone having either an α-carboalkoxy or α-acyl group with N-bromosuccinimide and thermally cyclizing the resulting bromine containing intermediate.
