64359-28-0Relevant academic research and scientific papers
Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes
Fan, Zhoulong,Lu, Heng,Li, Wei,Geng, Kaijun,Zhang, Ao
, p. 5701 - 5708 (2017)
A switchable synthesis of N-substituted indole derivatives from phenidones via rhodium-catalyzed redox-neutral C-H activation has been achieved. In this protocol, we firstly disclosed that the reactivity of Rh(iii) catalysis could be enhanced through employing palladium acetate as an additive. Some representative features include external oxidant-free, applicable to terminal alkynes, short reaction time and operational simplicity. The utility of this method is further showcased by the economical synthesis of potent anticancer PARP-1 inhibitors.
Ruthenium-catalyzed redox-neutral C-H activation via N-N cleavage: Synthesis of N-substituted indoles
Zhang, Zhenxing,Jiang, Hao,Huang, Yong
supporting information, p. 5976 - 5979 (2015/01/08)
The first Ru-catalyzed redox-neutral C-H activation reaction via N-N bond cleavage is reported. Pyrazolidin-3-one is demonstrated as an internally oxidative directing group that enables C-H annulation reactions with a broad scope of alkynes, including previously incompetent terminal alkynes. Pharmacologically privileged 3-(1H-indol-1-yl)propanamides were synthesized in high yields.
2-Substituted-indole-1-lower-alkanecarboxamides
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, (2008/06/13)
2-Substituted-indole-1-lower-alkanecarboxamides, prepared by amidation of the corresponding acid or ester; by hydrolysis or thiohydrolysis of the corresponding carbonitrile; by alkylation of a suitable indole with a halo-lower-alkanecarboxamide; or by hydrolysis of a 1-indolechlorosulfonylcarbamyl derivative, have anti-secretory and anti-ulcer activities.
