64359-28-0

Basic information

• Product Name: 1H-Indole-1-propanamide, 3-methyl-2-phenyl-
• CAS NO: 64359-28-0
• Molecular Formula: C18H18N2O
• Molecular Weight: 278.354
• Mol File: 64359-28-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-propanamide, 3-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-propanamide, 3-methyl-2-phenyl-(64359-28-0)
• EPA Substance Registry System: 1H-Indole-1-propanamide, 3-methyl-2-phenyl-(64359-28-0)

Safety Data

• Hazardous Substances Data: 64359-28-0(Hazardous Substances Data)

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 92-43-3 1-phenylpyrazolidin-3-one 

Relevant articles and documents

Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes

A switchable synthesis of N-substituted indole derivatives from phenidones via rhodium-catalyzed redox-neutral C-H activation has been achieved. In this protocol, we firstly disclosed that the reactivity of Rh(iii) catalysis could be enhanced through employing palladium acetate as an additive. Some representative features include external oxidant-free, applicable to terminal alkynes, short reaction time and operational simplicity. The utility of this method is further showcased by the economical synthesis of potent anticancer PARP-1 inhibitors.

2-Substituted-indole-1-lower-alkanecarboxamides

2-Substituted-indole-1-lower-alkanecarboxamides, prepared by amidation of the corresponding acid or ester; by hydrolysis or thiohydrolysis of the corresponding carbonitrile; by alkylation of a suitable indole with a halo-lower-alkanecarboxamide; or by hydrolysis of a 1-indolechlorosulfonylcarbamyl derivative, have anti-secretory and anti-ulcer activities.