64369-13-7

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-bromophenyl)-2,3-dihydro-1H-perimidine is used as a building block for the synthesis of various bioactive molecules, including those with potential antitumor, antiviral, and other pharmacological activities.
Used in Organic Synthesis:
2-(4-bromophenyl)-2,3-dihydro-1H-perimidine is used as an intermediate in organic synthesis, allowing for the modification and production of a wide range of derivatives with diverse properties and applications.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 479-27-6 naphthalene-1,8-diamine 

Relevant academic research and scientific papers

Application of SiO 2 nanoparticles as an efficient catalyst to develop syntheses of perimidines and tetraketones

Abstract: In this paper, we explore the catalytic activity of SiO 2 nanoparticles (NPs) as an eco-friendly, efficient and reusable catalyst in the synthesis of 2,3-dihydro-1H-perimidines as well as tetraketones. For tetraketones syntheses, a si

(Triazinediyl)bis sulfamic acid-functionalized silica-coated magnetite nanoparticles: Preparation, characterization and application as an efficient catalyst for synthesis of mono-, bis-, tris- and spiro-perimidines

(Triazinediyl)bis sulfamic acid-functionalized silica-coated magnetite nanoparticles have been prepared and applicated as an efficient catalyst for synthesis of mono-, bis-, tris- and spiro-perimidines. The desired products have been synthesized in high p

A class of 2, 3 - dihydronaphth block pyrimidine analogs, its synthetic method, pharmaceutical composition and use thereof

The invention belongs to the technical field of medicines and relates to a 2,3-dihydronaphthalene-embedded m-diazabenzene analogue represented as the following general formula I and a preparation method thereof. The 2,3-dihydronaphthalene-embedded m-diazabenzene analogue has a function of inhibiting biological activities of different subtypes of a protein-tyrosine-phosphatase family (PTPases), can be used as a tool compound for researching a biological function correlation of the subtypes of the protein-tyrosine-phosphatase family (PTPases) in a cell signal transduction process, and provides a new approach for preventing and treating cancer, metabolic and immunological diseases, angiocardiopathy and neurological diseases.

1H-2,3-Dihydroperimidine derivatives: A new class of potent protein Tyrosine Phosphatase 1B inhibitors

A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivity (3.48-fold and 2.10-fold respectively) over T-cell protein tyrosine phosphatases (TCPTP). These results have provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.