6437-48-5

Usage

Uses

Used in Fragrance Industry:
1-(3-METHYLPHENOXY)-2-PROPANONE is used as a fragrance ingredient for its sweet, floral scent, contributing to the creation of various perfume compositions.
Used in Food Industry:
In the food industry, 1-(3-METHYLPHENOXY)-2-PROPANONE is utilized as a flavoring agent, enhancing the taste and aroma of different food products.
Used in Pharmaceutical Industry:
1-(3-METHYLPHENOXY)-2-PROPANONE is also employed in the synthesis of pharmaceuticals, where its chemical properties are leveraged to produce a range of medicinal compounds.
Used in Organic Chemistry:
1-(3-METHYLPHENOXY)-2-PROPANONE is further used in the synthesis of other organic compounds, showcasing its versatility in chemical reactions and its importance in the field of organic chemistry.
Safety:
Although 1-(3-METHYLPHENOXY)-2-PROPANONE is considered relatively safe with low toxicity and minimal environmental impact, it is crucial to adhere to proper handling and storage procedures to ensure the safety of individuals and the environment.

InChI:InChI=1/C10H12O2/c1-8-4-3-5-10(6-8)12-7-9(2)11/h3-6H,7H2,1-2H3

Upstream product

• 108-39-4 3-methyl-phenol 
• 78-95-5 chloroacetone 
• 3019-89-4 sodium 3-methylphenoxide 
• 598-31-2 1-bromoacetone 

Downstream Products

• 6437-47-4 1-(3-methylphenoxy)prop-2-ylamine 
• 18725-75-2 <3-Methyl-phenoxy>-aceton-dimethyl-ketal 
• 6560-16-3 1-m-Tolyloxy-propan-2-one oxime 
• 218770-31-1 1-(2-Cyclopropylidene-propoxy)-3-methyl-benzene 

Relevant academic research and scientific papers

Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes

Ventricular cardiac arrhythmia (VA) arises in acquired or congenital heart disease. Long QT syndrome type-3 (LQT3) is a congenital form of VA caused by cardiac sodium channel (INaL) SCN5A mutations that prolongs cardiac action potential (AP) and enhances INaL current. Mexiletine inhibits INaL and shortens the QT interval in LQT3 patients. Above therapeutic doses, mexiletine prolongs the cardiac AP. We explored structure-activity relationships (SAR) for AP shortening and prolongation using dynamic medicinal chemistry and AP kinetics in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Using patient-derived LQT3 and healthy hiPSC-CMs, we resolved distinct SAR for AP shortening and prolongation effects in mexiletine analogues and synthesized new analogues with enhanced potency and selectivity for INaL. This resulted in compounds with decreased AP prolongation effects, increased metabolic stability, increased INaL selectivity, and decreased avidity for the potassium channel. This study highlights using hiPSC-CMs to guide medicinal chemistry and "drug development in a dish".

Iridium-catalyzed enantioselective intramolecular hydroarylation of allylic aryl ethers devoid of a directing group on the aryl group

Although intramolecular hydroarylation is an attractive transformation of allylic aryl ethers, it has suffered from narrow substrate scope. We herein describe Ir/(S)-DTBM-SEGPHOS-catalyzed intramolecular hydroarylation of allylic aryl ethers. The reaction

Design, synthesis and effect of the introduction of a propargyloxy group on the fungicidal activities of 1-substituted phenoxypropan-2-amino valinamide carbamate derivatives

The cell walls of oomycetes are composed of cellulose, making cellulose synthase enzymes good targets for carboxylic acid amide fungicides. Valinamide carbamates are amino acid fungicides that represent excellent alternatives to conventional synthetic pesticides in terms of their ability to reduce the negative impacts of these compounds on human health and the environment. In a continuation of our research towards the development of new cellulose synthase inhibitors, we have developed a series of "stretched" analogues of iprovalicarb by the introduction of an additional OCH2 linker. The bioassay results indicated that compounds containing a small group at the para-position of phenyl gave excellent fungicidal activities with EC50 values ranging from 0.59 to 2.06 μmol L-1. Most notably, the introduction of a propargyloxy group led to a pronounced increase in the fungicidal activity. Furthermore, compound 7o bearing a propargyloxy group was identified as the most promising candidate because of its excellent fungicidal potency against oomycete diseases and good fungicidal activity against non-oomycete diseases.

Serotonin antagonists

A compound of the formula EQU1 or an acid addition salt thereof wherein R1 and R2 are the same or different and each is a phenyl or thien-2-yl group optionally substituted in one or more positions by a substituent selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy), each of the said phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy) substituent groups being optionally substituted in one or more positions by a member selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, and lower alkylthio; A1 is a divalent straight or branched alkylene group containing from two to six carbon atoms and one or two divalent atoms which are each an oxygen or sulphur atom, provided that there are at least two carbon atoms between the divalent atom and the --NH-- group and between the two divalent atoms; and A2 is the methylene group --CH2 --.