643763-10-4Relevant academic research and scientific papers
A concise synthesis of ortho-substituted aryl-acrylamides - Potent activators of soluble guanylyl cyclase
Zhang, Henry Q.,Xia, Zhiren,Kolasa, Teodozyj,Dinges, Jurgen
, p. 8661 - 8663 (2007/10/03)
Horner-Emmons reaction of phosphonate amides with aldehydes leads to generation of o-substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure-activity relationships (SAR) for soluble guanylyl cyclase (sGC)
