64388-86-9Relevant academic research and scientific papers
Design, synthesis and anti-mycobacterial activity of 1,2,3,5- tetrasubstituted pyrrolyl-N-acetic acid derivatives
Pagadala, Lakshmi Reddy,Mukkara, Lakshmi Devi,Singireddi, Satyanarayana,Singh, Ashita,Thummaluru, Veera Reddy,Jagarlamudi, Padma Sridevi,Guttala, Raja Sekhar,Perumal, Yogeeswari,Dharmarajan, Sriram,Upadhyayula, Suryanarayana Murty,Ummanni, Ramesh,Basireddy, Venkata Subba Reddy,Ravirala, Narender
, p. 118 - 126 (2014/07/22)
A novel synthesis of highly substituted pyrrole-N-acetic derivatives is described through the coupling of 1,4-diketones with amino acids following Paal-Knorr's approach. These pyrrole-N-acetic acid derivatives are found to exhibit potent anti-mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis strain H37Rv. In particular, 5n, 5q & 5r are found to display excellent anti-mycobacterial activity against M. tuberculosis strain H37Rv with MIC values in the range of 2.97 μM. Conversely, these compounds showed low cytotoxicity (selectivity index: >16.83) against HEK-293T cell line.
